The HTTP/2 protocol allows a denial of service (server resource consumption) because request cancellation can reset many streams quickly, as exploited in the wild in August through October 2023.
An HTTP Request Forgery issue was discovered in Varnish Cache 5.x and 6.x before 6.0.11, 7.x before 7.1.2, and 7.2.x before 7.2.1. An attacker may introduce characters through HTTP/2 pseudo-headers that are invalid in the context of an HTTP/1 request line, causing the Varnish server to produce invalid HTTP/1 requests to the backend. This could, in turn, be used to exploit vulnerabilities in a server behind the Varnish server. Note: the 6.0.x LTS series (before 6.0.11) is affected.
Varnish Cache, with HTTP/2 enabled, allows request smuggling and VCL authorization bypass via a large Content-Length header for a POST request. This affects Varnish Enterprise 6.0.x before 6.0.8r3, and Varnish Cache 5.x and 6.x before 6.5.2, 6.6.x before 6.6.1, and 6.0 LTS before 6.0.8.
vbf_stp_error in bin/varnishd/cache/cache_fetch.c in Varnish HTTP Cache 4.1.x before 4.1.9 and 5.x before 5.2.1 allows remote attackers to obtain sensitive information from process memory because a VFP_GetStorage buffer is larger than intended in certain circumstances involving -sfile Stevedore transient objects.