SilverStripe through 4.6.0-rc1 has an XXE Vulnerability in CSSContentParser. A developer utility meant for parsing HTML within unit tests can be vulnerable to XML External Entity (XXE) attacks. When this developer utility is misused for purposes involving external or user submitted data in custom project code, it can lead to vulnerabilities such as XSS on HTML output rendered through this custom code. This is now mitigated by disabling external entities during parsing. (The correct CVE ID year is 2020 [CVE-2020-25817, not CVE-2021-25817]).
In SilverStripe through 4.5, malicious users with a valid Silverstripe CMS login (usually CMS access) can craft profile information which can lead to XSS for other users through specially crafted login form URLs.
Silverstripe CMS sites through 4.4.4 which have opted into HTTP Cache Headers on responses served by the framework's HTTP layer can be vulnerable to web cache poisoning. Through modifying the X-Original-Url and X-HTTP-Method-Override headers, responses with malicious HTTP headers can return unexpected responses to other consumers of this cached response. Most other headers associated with web cache poisoning are already disabled through request hostname forgery whitelists.