Python Packaging Authority (PyPA) setuptools before 65.5.1 allows remote attackers to cause a denial of service via HTML in a crafted package or custom PackageIndex page. There is a Regular Expression Denial of Service (ReDoS) in package_index.py.
easy_install in setuptools before 0.7 uses HTTP to retrieve packages from the PyPI repository, and does not perform integrity checks on package contents, which allows man-in-the-middle attackers to execute arbitrary code via a crafted response to the default use of the product.