In mutt and neomutt the In-Reply-To email header field is not protected by cryptographic signing which allows an attacker to reuse an unencrypted but signed email message to impersonate the original sender.
In mutt and neomutt, PGP encryption does not use the --hidden-recipient mode which may leak the Bcc email header field by inferring from the recipients info.
In neomutt and mutt, the To and Cc email headers are not validated by cryptographic signing which allows an attacker that intercepts a message to change their value and include himself as a one of the recipients to compromise message confidentiality.
Mutt 1.11.0 through 2.0.x before 2.0.7 (and NeoMutt 2019-10-25 through 2021-05-04) has a $imap_qresync issue in which imap/util.c has an out-of-bounds read in situations where an IMAP sequence set ends with a comma. NOTE: the $imap_qresync setting for QRESYNC is not enabled by default.
rfc822.c in Mutt through 2.0.4 allows remote attackers to cause a denial of service (mailbox unavailability) by sending email messages with sequences of semicolon characters in RFC822 address fields (aka terminators of empty groups). A small email message from the attacker can cause large memory consumption, and the victim may then be unable to see email messages from other persons.
Mutt before 2.0.2 and NeoMutt before 2020-11-20 did not ensure that $ssl_force_tls was processed if an IMAP server's initial server response was invalid. The connection was not properly closed, and the code could continue attempting to authenticate. This could result in authentication credentials being exposed on an unencrypted connection, or to a machine-in-the-middle.
Mutt before 1.14.4 and NeoMutt before 2020-06-19 have a STARTTLS buffering issue that affects IMAP, SMTP, and POP3. When a server sends a "begin TLS" response, the client reads additional data (e.g., from a man-in-the-middle attacker) and evaluates it in a TLS context, aka "response injection."