The on_get_missing_events function in handlers/federation.py in Matrix Synapse before 0.31.1 has a security bug in the get_missing_events federation API where event visibility rules were not applied correctly.
Matrix Synapse before 0.28.1 is prone to a denial of service flaw where malicious events injected with depth = 2^63 - 1 render rooms unusable, related to federation/federation_base.py and handlers/message.py, as exploited in the wild in April 2018.
Matrix FTP Server allows remote attackers to cause a denial of service (crash) by logging in using four spaces as the username and password and then issuing a LIST command.