Trend OfficeScan Corporate Edition 5.58 and possibly earler does not drop privileges when opening a help window from a virus detection pop-up window, which allows local users to gain SYSTEM privileges.
Trend Micro OfficeScan 3.0 - 6.0 has default permissions of "Everyone Full Control" on the installation directory and registry keys, which allows local users to disable virus protection.
The default installation of Trend Micro OfficeScan 3.0 through 3.54 and 5.x allows remote attackers to bypass authentication from cgiChkMasterPasswd.exe and gain access to the web management console via a direct request to cgiMasterPwd.exe.
Buffer overflow in pop3trap.exe for PC-cillin 2000, 2002, and 2003 allows local users to execute arbitrary code via a long input string to TCP port 110 (POP3).
Trend Micro OfficeScan Corporate Edition (aka Virus Buster) 3.53 allows remote attackers to access sensitive information from the hotdownload directory without authentication, such as the ofcscan.ini configuration file, which contains a weakly encrypted password.
The Trend Micro OfficeScan client allows remote attackers to cause a denial of service by making 5 connections to port 12345, which raises CPU utilization to 100%.